Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay

Cell-based assays for CDK8/19 inhibition are not easily defined, since there are no known cellular functions unique to these kinases. To solve this problem, we generated derivatives of 293 cells with CRISPR knockout of one or both of CDK8 and CDK19. Double knockout (dKO) of CDK8 and CDK19 together (...

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Detalles Bibliográficos
Autores principales: Li, Jing, Ji, Hao, Porter, Donald C., Broude, Eugenia V., Roninson, Igor B., Chen, Mengqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830309/
https://www.ncbi.nlm.nih.gov/pubmed/31590445
http://dx.doi.org/10.3390/cells8101208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830309/
https://www.ncbi.nlm.nih.gov/pubmed/31590445
http://dx.doi.org/10.3390/cells8101208

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