CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

SF3B1 is the most frequently mutated splicing factor in cancer. Mutations in SF3B1 likely confer clonal advantages to cancer cells but they may also confer vulnerabilities that can be therapeutically targeted. SF3B1 cancer mutations can be maintained in homozygosis in C. elegans, allowing synthetic...

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Detalles Bibliográficos
Autores principales: Serrat, Xènia, Kukhtar, Dmytro, Cornes, Eric, Esteve-Codina, Anna, Benlloch, Helena, Cecere, Germano, Cerón, Julián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830814/
https://www.ncbi.nlm.nih.gov/pubmed/31634348
http://dx.doi.org/10.1371/journal.pgen.1008464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830814/
https://www.ncbi.nlm.nih.gov/pubmed/31634348
http://dx.doi.org/10.1371/journal.pgen.1008464

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