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The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling
TLRs, including TLR4, have been shown to play a crucial role in cardiovascular inflammatory-based diseases. The main goal of this study was to determine the potential of FP7, a synthetic glycolipid active as a TLR4 antagonist, to modulate haematopoietic and non-haematopoietic vascular TLR4 pro-infla...
Autores principales: | Palmer, Charys, Peri, Francesco, Neumann, Frank, Ahmad, Feroz, Leake, David S., Pirianov, Grisha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830872/ https://www.ncbi.nlm.nih.gov/pubmed/30208782 http://dx.doi.org/10.1177/1753425918798904 |
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