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Ephrin-B2 inhibits cell proliferation and motility in vitro and predicts longer metastasis-free survival in breast cancer

The tyrosine kinase receptor EphB4 and its ligand ephrin-B2 interact through cell-to-cell contacts. Upon interaction, EphB4 transmits bidirectional signals. A forward signal inside EphB4-expressing cells is believed to suppress tumor growth, while inside the ephrin-expressing cells, an oncogenic rev...

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Detalles Bibliográficos
Autores principales: Magic, Zeljana, Sandström, Josefine, Perez-Tenorio, Gizeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831205/
https://www.ncbi.nlm.nih.gov/pubmed/31638179
http://dx.doi.org/10.3892/ijo.2019.4892