Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

Background: The dense fibrotic stroma enveloping pancreatic tumors is a major cause of drug resistance. Pancreatic stellate cells (PSCs) in the stroma can be activated to induce intra-tumor fibrosis and worsen patient survival; however, the molecular basics for the regulation of PSC activation remai...

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Detalles Bibliográficos
Autores principales: Wang, Hao-Chen, Lin, Yung-Lun, Hsu, Ching-Cheng, Chao, Ying-Jui, Hou, Ya-Chin, Chiu, Tai-Jan, Huang, Po-Hsien, Tang, Ming-Jer, Chen, Li-Tzong, Shan, Yan-Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831292/
https://www.ncbi.nlm.nih.gov/pubmed/31695760
http://dx.doi.org/10.7150/thno.36830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831292/
https://www.ncbi.nlm.nih.gov/pubmed/31695760
http://dx.doi.org/10.7150/thno.36830

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