Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing

Rationale: Mutations of SLC26A4 that abrogate pendrin, expressed in endolymphatic sac, cochlea and vestibule, are known to cause autosomal recessive sensorineural hearing loss with enlargement of the membranous labyrinth. This is the first study to demonstrate the feasibility of gene therapy for pen...

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Detalles Bibliográficos
Autores principales: Kim, Min-A, Kim, Sung Huhn, Ryu, Nari, Ma, Ji-Hyun, Kim, Ye-Ri, Jung, Jinsei, Hsu, Chuan-Jen, Choi, Jae Young, Lee, Kyu-Yup, Wangemann, Philine, Bok, Jinwoong, Kim, Un-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831294/
https://www.ncbi.nlm.nih.gov/pubmed/31695761
http://dx.doi.org/10.7150/thno.38032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831294/
https://www.ncbi.nlm.nih.gov/pubmed/31695761
http://dx.doi.org/10.7150/thno.38032

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