Cargando…

HBX-induced miR-5188 impairs FOXO1 to stimulate β-catenin nuclear translocation and promotes tumor stemness in hepatocellular carcinoma

Cancer stem cells (CSCs) are the key factor in determining cancer recurrence, metastasis, chemoresistance and patient prognosis in hepatocellular carcinoma (HCC). The role of miR-5188 in cancer stemness has never been documented. In this study, we investigated the clinical and biological roles of mi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Xian, Zuo, Shi, Luo, Rongcheng, Li, Yonghao, Yu, Guifang, Zou, Yujiao, Zhou, Yan, Liu, Zhan, Liu, Yiyi, Hu, Yingying, Xie, Yingying, Fang, Weiyi, Liu, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831466/ https://www.ncbi.nlm.nih.gov/pubmed/31695788 http://dx.doi.org/10.7150/thno.37717

Ejemplares similares

miR-1254 induced by NESG1 inactivates HDGF/DDX5-stimulated nuclear translocation of β-catenin and suppresses NPC metastasis
por: Cheng, Chao, et al.
Publicado: (2021)

miR‐5188 augments glioma growth, migration and invasion through an SP1‐modulated FOXO1‐PI3K/AKT‐c‐JUN‐positive feedback circuit
por: Yi, Renhui, et al.
Publicado: (2020)

Transcriptomic identification of HBx-associated hub genes in hepatocellular carcinoma
por: Ni, Zhengzhong, et al.
Publicado: (2021)

SYVN1 ubiquitinates FoxO1 to induce β-catenin nuclear translocation, PD-L1-mediated metastasis, and immune evasion of hepatocellular carcinoma
por: Xie, Wei, et al.
Publicado: (2023)

Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma
por: Lin, Xian, et al.
Publicado: (2020)

Nuclear translocation of beta-catenin in colorectal cancer
por: Kobayashi, M, et al.
Publicado: (2000)

HBx‐mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis
por: Chen, Shi‐Lu, et al.
Publicado: (2017)

HBx Gene Mutations in Hepatitis B Virus and Hepatocellular Carcinoma
por: Mathew M, Anumol, et al.
Publicado: (2014)

Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin
por: Simcha, Inbal, et al.
Publicado: (1998)

C-Terminal Truncated HBx Facilitates Oncogenesis by Modulating Cell Cycle and Glucose Metabolism in FXR-Deficient Hepatocellular Carcinoma
por: Wu, Xuejun, et al.
Publicado: (2023)

UBE2T promotes β‐catenin nuclear translocation in hepatocellular carcinoma through MAPK/ERK‐dependent activation
por: Lioulia, Elisavet, et al.
Publicado: (2022)

USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells
por: Qian, Yu, et al.
Publicado: (2016)

HBx mutations promote hepatoma cell migration through the Wnt/β‐catenin signaling pathway
por: Chen, Zhen, et al.
Publicado: (2016)

Mechanism of HBx carcinogenesis interaction with non-coding RNA in hepatocellular carcinoma
por: Wang, Zhuoran, et al.
Publicado: (2023)

miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
por: Zhao, Mengyang, et al.
Publicado: (2016)

IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
por: Tian, Miao, et al.
Publicado: (2020)

Author Correction: miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
por: Zhao, Mengyang, et al.
Publicado: (2021)

Dual roles of miR-374a by modulated c-Jun respectively targets CCND1-inducing PI3K/AKT signal and PTEN-suppressing Wnt/β-catenin signaling in non-small-cell lung cancer
por: Zhao, Mengyang, et al.
Publicado: (2018)

HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma
por: Liu, L-p, et al.
Publicado: (2014)

Retraction Note: Dual roles of miR-374a by modulated c-Jun respectively targets CCND1-inducing PI3K/AKT signal and PTEN-suppressing Wnt/β-catenin signaling in non-small-cell lung cancer
por: Zhao, Mengyang, et al.
Publicado: (2021)

miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway
por: Tang, ZiBo, et al.
Publicado: (2020)

The Role of HBx Protein in Diseases Beyond the Liver
por: Ai, Liping, et al.
Publicado: (2023)

Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway
por: Liu, Yiyi, et al.
Publicado: (2019)

JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression
por: Lei, Hu, et al.
Publicado: (2022)

β-catenin nuclear translocation induced by HIF-1α overexpression leads to the radioresistance of prostate cancer
por: Luo, Yong, et al.
Publicado: (2018)

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress
por: Wang, Ming-Da, et al.
Publicado: (2016)

Interferon-α sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation
por: Liu, Yanning, et al.
Publicado: (2013)

Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx
por: Hensel, Kai O., et al.
Publicado: (2018)

Author Correction: IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
por: Tian, Miao, et al.
Publicado: (2023)

HBx sensitizes hepatocellular carcinoma cells to lapatinib by up-regulating ErbB3
por: Chen, Jhen-Yu, et al.
Publicado: (2015)

HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis
por: Wang, Qing, et al.
Publicado: (2020)

Utilizing Experimental Mouse Model to Identify Effectors of Hepatocellular Carcinoma Induced by HBx Antigen
por: Yang, Ming-Hui, et al.
Publicado: (2020)

A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis
por: Qu, Siming, et al.
Publicado: (2021)

Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma
por: Medhat, Arvin, et al.
Publicado: (2021)

Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice
por: McBrearty, Noreen, et al.
Publicado: (2021)

HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis
por: Dong, Mei-Ling, et al.
Publicado: (2022)

The effect of S100A6 on nuclear translocation of CacyBP/SIP in colon cancer cells
por: Feng, Shanshan, et al.
Publicado: (2018)

Autophagic Degradation of Misfolded Nuclear Receptor Co-repressor (NCoR) Is Linked to the Growth of Tumor Cells in HBX Positive Hepatocellular Carcinoma (HCC)
por: Tan, Su Yin, et al.
Publicado: (2019)

The Effect of miR-338-3p on HBx Deletion-Mutant (HBx-d382) Mediated Liver-Cell Proliferation through CyclinD1 Regulation
por: Fu, Xiaoyu, et al.
Publicado: (2012)

P120 regulates beta-catenin nuclear translocation through E-cadherin endocytosis in ventilator-induced lung injury
por: Gu, Changping, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l1gkdajp6u4sllioo2l4j9v3tb