Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model

The development of effective central nervous system (CNS) drugs has been hampered by the lack of robust strategies to mimic the blood-brain barrier (BBB) and cerebrovascular impairments in vitro. Recent technological advancements in BBB modeling using induced pluripotent stem cells (iPSCs) allowed t...

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Detalles Bibliográficos
Autores principales: Roux, Gwenaëlle Le, Jarray, Rafika, Guyot, Anne-Cécile, Pavoni, Serena, Costa, Narciso, Théodoro, Frédéric, Nassor, Ferid, Pruvost, Alain, Tournier, Nicolas, Kiyan, Yulia, Langer, Oliver, Yates, Frank, Deslys, Jean Philippe, Mabondzo, Aloïse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831611/
https://www.ncbi.nlm.nih.gov/pubmed/31690750
http://dx.doi.org/10.1038/s41598-019-52213-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831611/
https://www.ncbi.nlm.nih.gov/pubmed/31690750
http://dx.doi.org/10.1038/s41598-019-52213-6

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