Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction

We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling. The CBs, Δ(9)-THC, cannabidiol, HU-210, and CP 55,940 caused alcohol-like effects on craniofacial and brain develo...

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Detalles Bibliográficos
Autores principales: Fish, Eric W., Murdaugh, Laura B., Zhang, Chengjin, Boschen, Karen E., Boa-Amponsem, Oswald, Mendoza-Romero, Haley N., Tarpley, Michael, Chdid, Lhoucine, Mukhopadhyay, Somnath, Cole, Gregory J., Williams, Kevin P., Parnell, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831672/
https://www.ncbi.nlm.nih.gov/pubmed/31690747
http://dx.doi.org/10.1038/s41598-019-52336-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831672/
https://www.ncbi.nlm.nih.gov/pubmed/31690747
http://dx.doi.org/10.1038/s41598-019-52336-w

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