Kinetic Control of Parallel versus Antiparallel Amyloid Aggregation via Shape of the Growing Aggregate

By combining atomistic and higher-level modelling with solution X-ray diffraction we analyse self-assembly pathways for the IFQINS hexapeptide, a bio-relevant amyloid former derived from human lysozyme. We verify that (at least) two metastable polymorphic structures exist for this system which are s...

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Detalles Bibliográficos
Autores principales: Zanjani, Ali Asghar Hakami, Reynolds, Nicholas P., Zhang, Afang, Schilling, Tanja, Mezzenga, Raffaele, Berryman, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831816/
https://www.ncbi.nlm.nih.gov/pubmed/31690748
http://dx.doi.org/10.1038/s41598-019-52238-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831816/
https://www.ncbi.nlm.nih.gov/pubmed/31690748
http://dx.doi.org/10.1038/s41598-019-52238-x

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