A conserved motif liganding the [4Fe–4S] cluster in [4Fe–4S] fumarases prevents irreversible inactivation of the enzyme during hydrogen peroxide stress

Organisms have evolved two different classes of the ubiquitous enzyme fumarase: the [4Fe–4S] cluster-containing class I enzymes are oxidant-sensitive, whereas the class II enzymes are iron-free and therefore oxidant-resistant. When hydrogen peroxide (H(2)O(2)) attacks the most-studied [4Fe–4S] fumar...

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Detalles Bibliográficos
Autores principales: Lu, Zheng, Imlay, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831887/
https://www.ncbi.nlm.nih.gov/pubmed/31465957
http://dx.doi.org/10.1016/j.redox.2019.101296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831887/
https://www.ncbi.nlm.nih.gov/pubmed/31465957
http://dx.doi.org/10.1016/j.redox.2019.101296

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