NPC1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP46A1 activation

NPC is a neurodegenerative disorder characterized by cholesterol accumulation in endolysosomal compartments. It is caused by mutations in the gene encoding NPC1, an endolysosomal protein mediating intracellular cholesterol trafficking. Cognitive and psychiatric alterations are hallmarks in NPC patie...

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Detalles Bibliográficos
Autores principales: Mitroi, Daniel N, Pereyra‐Gómez, Guadalupe, Soto‐Huelin, Beatriz, Senovilla, Fernando, Kobayashi, Toshihide, Esteban, Jose A, Ledesma, María Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832102/
https://www.ncbi.nlm.nih.gov/pubmed/31535451
http://dx.doi.org/10.15252/embr.201948143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832102/
https://www.ncbi.nlm.nih.gov/pubmed/31535451
http://dx.doi.org/10.15252/embr.201948143

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