Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments

The detection of catalytically active botulinum neurotoxins (BoNTs) can be achieved by monitoring the enzymatic cleavage of soluble NSF (N-ethylmaleimide-sensitive-factor) attachment protein receptor (SNARE) proteins by the toxins’ light chains (LC) in cleavage-based assays. Thus, for sensitive BoNT...

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Detalles Bibliográficos
Autores principales: von Berg, Laura, Stern, Daniel, Weisemann, Jasmin, Rummel, Andreas, Dorner, Martin Bernhard, Dorner, Brigitte Gertrud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832249/
https://www.ncbi.nlm.nih.gov/pubmed/31614566
http://dx.doi.org/10.3390/toxins11100588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832249/
https://www.ncbi.nlm.nih.gov/pubmed/31614566
http://dx.doi.org/10.3390/toxins11100588

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