Base-Promoted Chemodivergent Formation of 1,4-Benzoxazepin-5(4H)-ones and 1,3-Benzoxazin-4(4H)-ones Switched by Solvents

The KOH-promoted chemodivergent benzannulation of ortho-fluorobenzamides with 2-propyn-1-ol can afford either 1,4-benzoxazepin-5(4H)-ones or 1,3-benzoxazin-4(4H)-ones in good yields with high selectivity, depending greatly upon the use of solvents. In the case of using DMSO, the intermolecular benza...

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Detalles Bibliográficos
Autores principales: Chen, Qian, Wang, Yunpeng, Hua, Ruimao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832296/
https://www.ncbi.nlm.nih.gov/pubmed/31635103
http://dx.doi.org/10.3390/molecules24203773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832296/
https://www.ncbi.nlm.nih.gov/pubmed/31635103
http://dx.doi.org/10.3390/molecules24203773

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