Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide

The total synthesis of potent anti-obesity lansiumamide B was accomplished in four steps using commercially available materials. The synthetic strategy, featured with copper-catalyzed Buchwald coupling, is concise, convergent, practical and can be carried out on a one-gram scale. This approach could...

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Detalles Bibliográficos
Autores principales: Lin, Ran, Lin, Xi, Su, Qian, Guo, Binbin, Huang, Yanqin, Ouyang, Ming-An, Song, Liyan, Xu, Huiyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832413/
https://www.ncbi.nlm.nih.gov/pubmed/31635023
http://dx.doi.org/10.3390/molecules24203764
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author Lin, Ran
Lin, Xi
Su, Qian
Guo, Binbin
Huang, Yanqin
Ouyang, Ming-An
Song, Liyan
Xu, Huiyou
author_facet Lin, Ran
Lin, Xi
Su, Qian
Guo, Binbin
Huang, Yanqin
Ouyang, Ming-An
Song, Liyan
Xu, Huiyou
author_sort Lin, Ran
collection PubMed
description The total synthesis of potent anti-obesity lansiumamide B was accomplished in four steps using commercially available materials. The synthetic strategy, featured with copper-catalyzed Buchwald coupling, is concise, convergent, practical and can be carried out on a one-gram scale. This approach could give either Z- or E-configured enamide moiety in natural products with absolute stereocontrol and was applied in the total synthesis of natural products.
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spelling pubmed-68324132019-11-25 Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide Lin, Ran Lin, Xi Su, Qian Guo, Binbin Huang, Yanqin Ouyang, Ming-An Song, Liyan Xu, Huiyou Molecules Communication The total synthesis of potent anti-obesity lansiumamide B was accomplished in four steps using commercially available materials. The synthetic strategy, featured with copper-catalyzed Buchwald coupling, is concise, convergent, practical and can be carried out on a one-gram scale. This approach could give either Z- or E-configured enamide moiety in natural products with absolute stereocontrol and was applied in the total synthesis of natural products. MDPI 2019-10-19 /pmc/articles/PMC6832413/ /pubmed/31635023 http://dx.doi.org/10.3390/molecules24203764 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lin, Ran
Lin, Xi
Su, Qian
Guo, Binbin
Huang, Yanqin
Ouyang, Ming-An
Song, Liyan
Xu, Huiyou
Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide
title Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide
title_full Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide
title_fullStr Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide
title_full_unstemmed Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide
title_short Concise and Gram-Scale Total Synthesis of Lansiumamides A and B and Alatamide
title_sort concise and gram-scale total synthesis of lansiumamides a and b and alatamide
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832413/
https://www.ncbi.nlm.nih.gov/pubmed/31635023
http://dx.doi.org/10.3390/molecules24203764
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