Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immunotoxins have arisen as promising antitumor therapeutic...

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Detalles Bibliográficos
Autores principales: Ruiz-de-la-Herrán, Javier, Tomé-Amat, Jaime, Lázaro-Gorines, Rodrigo, Gavilanes, José G., Lacadena, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832446/
https://www.ncbi.nlm.nih.gov/pubmed/31614771
http://dx.doi.org/10.3390/toxins11100593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832446/
https://www.ncbi.nlm.nih.gov/pubmed/31614771
http://dx.doi.org/10.3390/toxins11100593

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