Novel Mutations Evading Avian Immunity around the Receptor Binding Site of the Clade 2.3.2.1c Hemagglutinin Gene Reduce Viral Thermostability and Mammalian Pathogenicity

Since 2007, highly pathogenic clade 2.3.2 H5N1 avian influenza A (A(H5N1)) viruses have evolved to clade 2.3.2.1a, b, and c; currently only 2.3.2.1c A(H5N1) viruses circulate in wild birds and poultry. During antigenic evolution, clade 2.3.2.1a and c A(H5N1) viruses acquired both S144N and V223I mut...

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Detalles Bibliográficos
Autores principales: An, Se-Hee, Lee, Chung-Young, Hong, Seung-Min, Song, Chang-Seon, Kim, Jae-Hong, Kwon, Hyuk-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832455/
https://www.ncbi.nlm.nih.gov/pubmed/31600990
http://dx.doi.org/10.3390/v11100923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832455/
https://www.ncbi.nlm.nih.gov/pubmed/31600990
http://dx.doi.org/10.3390/v11100923

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