12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells

Twenty new 12N-substituted matrinol derivatives were synthesized and evaluated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells. The structure-activity relationship (SAR) revealed that introducing a 12N-benzeneaminoacylmethyl substitution might s...

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Detalles Bibliográficos
Autores principales: Bao, Yunyang, Pang, Yudong, Tang, Sheng, Niu, Tianyun, Guo, Zhihao, He, Hongwei, Li, Yinghong, Song, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832694/
https://www.ncbi.nlm.nih.gov/pubmed/31627430
http://dx.doi.org/10.3390/molecules24203748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832694/
https://www.ncbi.nlm.nih.gov/pubmed/31627430
http://dx.doi.org/10.3390/molecules24203748

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