Cargando…
12N-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells
Twenty new 12N-substituted matrinol derivatives were synthesized and evaluated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells. The structure-activity relationship (SAR) revealed that introducing a 12N-benzeneaminoacylmethyl substitution might s...
Autores principales: | Bao, Yunyang, Pang, Yudong, Tang, Sheng, Niu, Tianyun, Guo, Zhihao, He, Hongwei, Li, Yinghong, Song, Danqing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832694/ https://www.ncbi.nlm.nih.gov/pubmed/31627430 http://dx.doi.org/10.3390/molecules24203748 |
Ejemplares similares
-
Structure–Activity Relationship of Aloperine Derivatives as New Anti–Liver Fibrogenic Agents
por: Wang, Kun, et al.
Publicado: (2020) -
Discovery of 9O-Substituted Palmatine Derivatives as a New Class of Anti-COL1A1 Agents Via Repressing TGF-β1/Smads and JAK1/STAT3 Pathways
por: Fan, Tianyun, et al.
Publicado: (2020) -
Discovery of Matrinic Thiadiazole Derivatives as a Novel Family of Anti-Liver Fibrosis Agents via Repression of the TGFβ/Smad Pathway
por: Niu, Tianyu, et al.
Publicado: (2018) -
Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells
por: Moran-Salvador, Eva, et al.
Publicado: (2019) -
Albumin fibrillization induces apoptosis via integrin/FAK/Akt pathway
por: Huang, Chun-Yung, et al.
Publicado: (2009)