Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents

A small and focused library of steroidal non-fused and fused pyrimidines was prepared from pregnenolone acetate and diosgenin, respectively. The key step was the cycloaddition reaction of nitrogen-containing 1,3-binucleophiles with the steroidal α,β-unsaturated ketone. Urea, thiourea and guanidine r...

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Detalles Bibliográficos
Autores principales: Cortés-Percino, Alejandra, Vega-Báez, José Luis, Romero-López, Anabel, Puerta, Adrián, Merino-Montiel, Penélope, Meza-Reyes, Socorro, Padrón, José M., Montiel-Smith, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832952/
https://www.ncbi.nlm.nih.gov/pubmed/31614780
http://dx.doi.org/10.3390/molecules24203676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832952/
https://www.ncbi.nlm.nih.gov/pubmed/31614780
http://dx.doi.org/10.3390/molecules24203676

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