The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors

A fragment-based drug discovery approach was taken to target the thiol-disulfide oxidoreductase enzyme DsbA from Escherichia coli (EcDsbA). This enzyme is critical for the correct folding of virulence factors in many pathogenic Gram-negative bacteria, and small molecule inhibitors can potentially be...

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Detalles Bibliográficos
Autores principales: Duncan, Luke F., Wang, Geqing, Ilyichova, Olga V., Scanlon, Martin J., Heras, Begoña, Abbott, Belinda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832960/
https://www.ncbi.nlm.nih.gov/pubmed/31635355
http://dx.doi.org/10.3390/molecules24203756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832960/
https://www.ncbi.nlm.nih.gov/pubmed/31635355
http://dx.doi.org/10.3390/molecules24203756

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