Internal Ribosome Entry Site Dramatically Reduces Transgene Expression in Hematopoietic Cells in a Position-Dependent Manner

Bicistronic transgene expression mediated by internal ribosome entry site (IRES) elements has been widely used. It co-expresses heterologous transgene products from a message RNA driven by a single promoter. Hematologic gene delivery is a promising treatment for both inherited and acquired diseases....

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Detalles Bibliográficos
Autores principales: Zheng, Qingyun, Zhang, Xueyan, Yang, Hua, Xie, Jinyan, Xie, Yilin, Chen, Jinzhong, Yu, Chenghui, Zhong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833044/
https://www.ncbi.nlm.nih.gov/pubmed/31597367
http://dx.doi.org/10.3390/v11100920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833044/
https://www.ncbi.nlm.nih.gov/pubmed/31597367
http://dx.doi.org/10.3390/v11100920

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