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De novo Nanopore read quality improvement using deep learning

BACKGROUND: Long read sequencing technologies such as Oxford Nanopore can greatly decrease the complexity of de novo genome assembly and large structural variation identification. Currently Nanopore reads have high error rates, and the errors often cluster into low-quality segments within the reads....

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Detalles Bibliográficos
Autores principales: LaPierre, Nathan, Egan, Rob, Wang, Wei, Wang, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833143/
https://www.ncbi.nlm.nih.gov/pubmed/31694525
http://dx.doi.org/10.1186/s12859-019-3103-z