Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

Apoptosis is a crucial process by which multicellular organisms control tissue growth, removal and inflammation. Disruption of the normal apoptotic function is often observed in cancer, where cell death is avoided by the overexpression of anti-apoptotic proteins of the Bcl-2 (B-cell lymphoma 2) fami...

Descripción completa

Detalles Bibliográficos
Autores principales: Luptak, Jakub, Bista, Michal, Fisher, David, Flavell, Liz, Gao, Ning, Wickson, Kate, Kazmirski, Steven L., Howard, Tina, Rawlins, Philip B., Hargreaves, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834078/
https://www.ncbi.nlm.nih.gov/pubmed/31692474
http://dx.doi.org/10.1107/S2059798319014116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834078/
https://www.ncbi.nlm.nih.gov/pubmed/31692474
http://dx.doi.org/10.1107/S2059798319014116

Ejemplares similares