Early Postnatal Treatment with Valproate Induces Gad1 Promoter Remodeling in the Brain and Reduces Apnea Episodes in Mecp2-Null Mice

The deletion of Mecp2, the gene encoding methyl-CpG-binding protein 2, causes severe breathing defects and developmental anomalies in mammals. In Mecp2-null mice, impaired GABAergic neurotransmission is demonstrated at the early stage of life. GABAergic dysfunction in neurons in the rostral ventrola...

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Detalles Bibliográficos
Autores principales: Ishiyama, Misa, Tamura, Satoko, Ito, Hisanori, Takei, Hiroki, Hoshi, Manami, Asano, Masatake, Itoh, Masayuki, Shirakawa, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834123/
https://www.ncbi.nlm.nih.gov/pubmed/31635390
http://dx.doi.org/10.3390/ijms20205177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834123/
https://www.ncbi.nlm.nih.gov/pubmed/31635390
http://dx.doi.org/10.3390/ijms20205177

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