Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution of drug resistance. We provide evidence that allel...

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Detalles Bibliográficos
Autores principales: Chevalier, Frédéric D., Le Clec’h, Winka, McDew-White, Marina, Menon, Vinay, Guzman, Meghan A., Holloway, Stephen P., Cao, Xiaohang, Taylor, Alexander B., Kinung'hi, Safari, Gouvras, Anouk N., Webster, Bonnie L., Webster, Joanne P., Emery, Aidan M., Rollinson, David, Garba Djirmay, Amadou, Al Mashikhi, Khalid M., Al Yafae, Salem, Idris, Mohamed A., Moné, Hélène, Mouahid, Gabriel, Hart, P. John, LoVerde, Philip T., Anderson, Timothy J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834289/
https://www.ncbi.nlm.nih.gov/pubmed/31652296
http://dx.doi.org/10.1371/journal.ppat.1007881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834289/
https://www.ncbi.nlm.nih.gov/pubmed/31652296
http://dx.doi.org/10.1371/journal.ppat.1007881

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