Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy

The PINK1 protein kinase activates the PARK2 ubiquitin ligase to promote mitochondrial ubiquitylation and recruitment of ubiquitin-binding mitophagy receptors typified by OPTN and TAX1BP1. Here, we combine proximity biotinylation of OPTN and TAX1BP1 with CRISPR-Cas9–based screens for mitophagic flux...

Descripción completa

Detalles Bibliográficos
Autores principales: Heo, Jin-Mi, Harper, Nathan J., Paulo, Joao A., Li, Mamie, Xu, Qikai, Coughlin, Margaret, Elledge, Stephen J., Harper, J. Wade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834391/
https://www.ncbi.nlm.nih.gov/pubmed/31723608
http://dx.doi.org/10.1126/sciadv.aay4624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834391/
https://www.ncbi.nlm.nih.gov/pubmed/31723608
http://dx.doi.org/10.1126/sciadv.aay4624

Ejemplares similares