Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse

Spinocerebellar ataxia type 3 (SCA3/MJD) is a polyQ neurodegenerative disease where the presymptomatic phase of pathogenesis is unknown. Therefore, we investigated the molecular network of transcriptomic and proteomic triggers in young presymptomatic SCA3/MJD brain from Ki91 knock-in mouse. We found...

Descripción completa

Detalles Bibliográficos
Autores principales: Wiatr, Kalina, Piasecki, Piotr, Marczak, Łukasz, Wojciechowski, Paweł, Kurkowiak, Małgorzata, Płoski, Rafał, Rydzanicz, Małgorzata, Handschuh, Luiza, Jungverdorben, Johannes, Brüstle, Oliver, Figlerowicz, Marek, Figiel, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834541/
https://www.ncbi.nlm.nih.gov/pubmed/31201651
http://dx.doi.org/10.1007/s12035-019-01643-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834541/
https://www.ncbi.nlm.nih.gov/pubmed/31201651
http://dx.doi.org/10.1007/s12035-019-01643-4

Ejemplares similares