Synergistic cancer immunotherapy combines MVA-CD40L induced innate and adaptive immunity with tumor targeting antibodies

Virus-based vaccines and appropriate costimulation potently enhance antigen-specific T cell immunity against cancer. Here we report the use of recombinant modified vaccinia virus Ankara (rMVA) encoding costimulatory CD40L against solid tumors. Therapeutic treatment with rMVA-CD40L-expressing tumor-a...

Descripción completa

Detalles Bibliográficos
Autores principales: Medina-Echeverz, José, Hinterberger, Maria, Testori, Marco, Geiger, Marlene, Giessel, Raphael, Bathke, Barbara, Kassub, Ronny, Gräbnitz, Fabienne, Fiore, Giovanna, Wennier, Sonia T., Chaplin, Paul, Suter, Mark, Hochrein, Hubertus, Lauterbach, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834557/
https://www.ncbi.nlm.nih.gov/pubmed/31695037
http://dx.doi.org/10.1038/s41467-019-12998-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834557/
https://www.ncbi.nlm.nih.gov/pubmed/31695037
http://dx.doi.org/10.1038/s41467-019-12998-6

Ejemplares similares