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Chemical activation of divergent protein tyrosine phosphatase domains with cyanine-based biarsenicals

Strategies for the direct chemical activation of specific signaling proteins could provide powerful tools for interrogating cellular signal transduction. However, targeted protein activation is chemically challenging, and few broadly applicable activation strategies for signaling enzymes have been d...

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Detalles Bibliográficos
Autores principales: Plaman, Bailey A., Chan, Wai Cheung, Bishop, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834593/
https://www.ncbi.nlm.nih.gov/pubmed/31695052
http://dx.doi.org/10.1038/s41598-019-52002-1