A Molecularly Detailed Na(V)1.5 Model Reveals a New Class I Antiarrhythmic Target

Antiarrhythmic treatment strategies remain suboptimal due to our inability to predict how drug interactions with ion channels will affect the ability of the tissues to initiate and sustain an arrhythmia. We built a multiscale molecular model of the Na(+) channel domain III (domain III voltage-sensin...

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Detalles Bibliográficos
Autores principales: Moreno, Jonathan D., Zhu, Wandi, Mangold, Kathryn, Chung, Woenho, Silva, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
TRANSLATIONAL MODEL
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834944/
https://www.ncbi.nlm.nih.gov/pubmed/31709321
http://dx.doi.org/10.1016/j.jacbts.2019.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834944/
https://www.ncbi.nlm.nih.gov/pubmed/31709321
http://dx.doi.org/10.1016/j.jacbts.2019.06.002

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