Indirubin 3′-Oxime Inhibits Migration, Invasion, and Metastasis InVivo in Mice Bearing Spontaneously Occurring Pancreatic Cancer via Blocking the RAF/ERK, AKT, and SAPK/JNK Pathways

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high invasive and metastatic potential. We generated a spontaneous PDAC mouse model and examined the therapeutic potential of indirubin 3′-oxime (Indox) against PDAC bearing mouse in vivo. METHODS: Randomized 3-month-ol...

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Detalles Bibliográficos
Autores principales: Ichimaru, Yoshimi, Sano, Makoto, Kajiwara, Ichie, Tobe, Takao, Yoshioka, Hiroki, Hayashi, Kazuhiko, Ijichi, Hideaki, Miyairi, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835019/
https://www.ncbi.nlm.nih.gov/pubmed/31671317
http://dx.doi.org/10.1016/j.tranon.2019.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835019/
https://www.ncbi.nlm.nih.gov/pubmed/31671317
http://dx.doi.org/10.1016/j.tranon.2019.08.010

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