Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients

Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by biallelic mutations in the MEFV gene, encoding Pyrin. Conclusive genetic evidence lacks for about 30% of patients diagnosed with clinical FMF. Pyrin is an inflammasome sens...

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Detalles Bibliográficos
Autores principales: Magnotti, Flora, Lefeuvre, Lucie, Benezech, Sarah, Malsot, Tiphaine, Waeckel, Louis, Martin, Amandine, Kerever, Sébastien, Chirita, Daria, Desjonqueres, Marine, Duquesne, Agnès, Gerfaud‐Valentin, Mathieu, Laurent, Audrey, Sève, Pascal, Popoff, Michel‐Robert, Walzer, Thierry, Belot, Alexandre, Jamilloux, Yvan, Henry, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835204/
https://www.ncbi.nlm.nih.gov/pubmed/31589380
http://dx.doi.org/10.15252/emmm.201910547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835204/
https://www.ncbi.nlm.nih.gov/pubmed/31589380
http://dx.doi.org/10.15252/emmm.201910547

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