Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions

Antibody-drug conjugates (ADCs) are a class of biotherapeutic drugs designed as targeted therapies for the treatment of cancer. Among the challenges in generating an effective ADC is the choice of an effective conjugation site on the IgG. One common method to prepare site-specific ADCs is to enginee...

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Detalles Bibliográficos
Autores principales: Gallagher, D. Travis, McCullough, Chris, Brinson, Robert G., Ahn, Joomi, Marino, John P., Dimasi, Nazzareno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835914/
https://www.ncbi.nlm.nih.gov/pubmed/31640157
http://dx.doi.org/10.3390/pharmaceutics11100546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835914/
https://www.ncbi.nlm.nih.gov/pubmed/31640157
http://dx.doi.org/10.3390/pharmaceutics11100546

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