Gellan Gum-Based Hydrogel for the Transdermal Delivery of Nebivolol: Optimization and Evaluation

Poor solubility and appreciable first-pass metabolism have limited the oral bioavailability of nebivolol. The objective of the current investigation was to design, formulate, and optimize a hydrogel-based transdermal system for nebivolol using factorial design and compare its pharmacokinetics with o...

Descripción completa

Detalles Bibliográficos
Autores principales: Nair, Anroop B., Shah, Jigar, Aljaeid, Bader M., Al-Dhubiab, Bandar E., Jacob, Shery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836162/
https://www.ncbi.nlm.nih.gov/pubmed/31623262
http://dx.doi.org/10.3390/polym11101699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836162/
https://www.ncbi.nlm.nih.gov/pubmed/31623262
http://dx.doi.org/10.3390/polym11101699

Ejemplares similares