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Global analyses of the dynamics of mammalian microRNA metabolism

Rates of production and degradation together specify microRNA (miRNA) abundance and dynamics. Here, we used approach-to-steady-state metabolic labeling to assess these rates for 176 miRNAs in contact-inhibited mouse embryonic fibroblasts (MEFs), 182 miRNAs in dividing MEFs, and 127 miRNAs in mouse e...

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Detalles Bibliográficos
Autores principales: Kingston, Elena R., Bartel, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836734/
https://www.ncbi.nlm.nih.gov/pubmed/31519739
http://dx.doi.org/10.1101/gr.251421.119