Temporal Modulation of HER2 Membrane Availability Increases Pertuzumab Uptake and Pretargeted Molecular Imaging of Gastric Tumors

Human epidermal growth factor receptor 2 (HER2) is used as a tumor biomarker and therapeutic target. Pertuzumab is an anti-HER2 antibody, and its binding to tumor cells requires HER2 to be present at the cell membrane. However, the cellular distribution of HER2 protein in gastric tumors is dynamic,...

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Detalles Bibliográficos
Autores principales: Pereira, Patrícia M.R., Mandleywala, Komal, Ragupathi, Ashwin, Carter, Lukas M., Goos, Jeroen A.C.M., Janjigian, Yelena Y., Lewis, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Nuclear Medicine 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836866/
https://www.ncbi.nlm.nih.gov/pubmed/31171598
http://dx.doi.org/10.2967/jnumed.119.225813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836866/
https://www.ncbi.nlm.nih.gov/pubmed/31171598
http://dx.doi.org/10.2967/jnumed.119.225813

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