Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHIKV in the Dominican Republic. Single B cell sortin...

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Detalles Bibliográficos
Autores principales: Quiroz, Jose A., Malonis, Ryan J., Thackray, Larissa B., Cohen, Courtney A., Pallesen, Jesper, Jangra, Rohit K., Brown, Rebecca S., Hofmann, Daniel, Holtsberg, Frederick W., Shulenin, Sergey, Nyakatura, Elisabeth K., Durnell, Lorellin A., Rayannavar, Vinayak, Daily, Johanna P., Ward, Andrew B., Aman, M. Javad, Dye, John M., Chandran, Kartik, Diamond, Michael S., Kielian, Margaret, Lai, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837291/
https://www.ncbi.nlm.nih.gov/pubmed/31697791
http://dx.doi.org/10.1371/journal.ppat.1008061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837291/
https://www.ncbi.nlm.nih.gov/pubmed/31697791
http://dx.doi.org/10.1371/journal.ppat.1008061

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