Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature

CRISPR-Cas is a powerful genome editing technology and has a great potential for in vivo gene therapy. Successful translational application of CRISPR-Cas to biomedicine still faces many safety concerns, including off-target side effect, cell fitness problem after CRISPR-Cas treatment, and on-target...

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Detalles Bibliográficos
Autores principales: Liu, Qiao, He, Di, Xie, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837542/
https://www.ncbi.nlm.nih.gov/pubmed/31658261
http://dx.doi.org/10.1371/journal.pcbi.1007480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837542/
https://www.ncbi.nlm.nih.gov/pubmed/31658261
http://dx.doi.org/10.1371/journal.pcbi.1007480

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