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Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence

Recent work has revealed that Clostridioides difficile, a major cause of nosocomial diarrheal disease, exhibits phenotypic heterogeneity within a clonal population as a result of phase variation. Many C. difficile strains representing multiple ribotypes develop two colony morphotypes, termed rough a...

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Detalles Bibliográficos
Autores principales: Garrett, Elizabeth M., Sekulovic, Ognjen, Wetzel, Daniela, Jones, Joshua B., Edwards, Adrianne N., Vargas-Cuebas, Germán, McBride, Shonna M., Tamayo, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837544/
https://www.ncbi.nlm.nih.gov/pubmed/31658249
http://dx.doi.org/10.1371/journal.pbio.3000379