A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants

[Image: see text] FR252921, FR252922, and FR256523 are a family of potent macrocyclic polyene immunosuppressive agents with a novel mode of action. However, the lack of an efficient and flexible synthesis has hindered further biological studies, mostly due to the fact that the natural products appea...

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Detalles Bibliográficos
Autores principales: Chen, Yong, Coussanes, Guilhem, Souris, Caroline, Aillard, Paul, Kaldre, Dainis, Runggatscher, Kathrin, Kubicek, Stefan, Di Mauro, Giovanni, Maryasin, Boris, Maulide, Nuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837725/
https://www.ncbi.nlm.nih.gov/pubmed/31436963
http://dx.doi.org/10.1021/jacs.9b07185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837725/
https://www.ncbi.nlm.nih.gov/pubmed/31436963
http://dx.doi.org/10.1021/jacs.9b07185

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