A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

PURPOSE: The intracellular fraction of unbound compound (f(u,cell)) is an important parameter for accurate prediction of drug binding to intracellular targets. f(u,cell) is the result of a passive distribution process of drug molecules partitioning into cellular structures. Initial observations in o...

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Detalles Bibliográficos
Autores principales: Treyer, Andrea, Walday, Sandra, Boriss, Hinnerk, Matsson, Pär, Artursson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838048/
https://www.ncbi.nlm.nih.gov/pubmed/31701258
http://dx.doi.org/10.1007/s11095-019-2717-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838048/
https://www.ncbi.nlm.nih.gov/pubmed/31701258
http://dx.doi.org/10.1007/s11095-019-2717-1

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