The biological activity of bispecific trastuzumab/pertuzumab plant biosimilars may be drastically boosted by disulfiram increasing formaldehyde accumulation in cancer cells

Studies of breast cancer therapy have examined the improvement of bispecific trastuzumab/pertuzumab antibodies interacting simultaneously with two different epitopes of the human epidermal growth factor receptor 2 (HER2). Here, we describe the creation and production of plant-made bispecific antibod...

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Detalles Bibliográficos
Autores principales: Komarova, Tatiana V., Sheshukova, Ekaterina V., Kosobokova, Ekaterina N., Kosorukov, Vyacheslav S., Shindyapina, Anastasia V., Lipskerov, Fedor A., Shpudeiko, Polina S., Byalik, Tatiana E., Dorokhov, Yuri L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838051/
https://www.ncbi.nlm.nih.gov/pubmed/31700025
http://dx.doi.org/10.1038/s41598-019-52507-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838051/
https://www.ncbi.nlm.nih.gov/pubmed/31700025
http://dx.doi.org/10.1038/s41598-019-52507-9

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