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Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute inflammatory vesiculobullous reactions of the skin and mucous membranes. These severe cutaneous drug reactions are known to be caused by inciting drugs and infectious agents. Previously, we have reported t...
Autores principales: | Nakatani, Ken, Ueta, Mayumi, Khor, Seik-Soon, Hitomi, Yuki, Okudaira, Yuko, Masuya, Anri, Wada, Yuki, Sotozono, Chie, Kinoshita, Shigeru, Inoko, Hidetoshi, Tokunaga, Katsushi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838058/ https://www.ncbi.nlm.nih.gov/pubmed/31700100 http://dx.doi.org/10.1038/s41598-019-52619-2 |
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