Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts

Designed armadillo repeat proteins (dArmRPs) bind extended peptides in a modular way. The consensus version recognises alternating arginines and lysines, with one dipeptide per repeat. For generating new binding specificities, the rapid and robust analysis by crystallography is key. Yet, we have pre...

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Detalles Bibliográficos
Autores principales: Ernst, Patrick, Honegger, Annemarie, van der Valk, Floor, Ewald, Christina, Mittl, Peer R. E., Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838082/
https://www.ncbi.nlm.nih.gov/pubmed/31700118
http://dx.doi.org/10.1038/s41598-019-52121-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838082/
https://www.ncbi.nlm.nih.gov/pubmed/31700118
http://dx.doi.org/10.1038/s41598-019-52121-9

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