Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit α(2)δ-1 with thrombospondin-4

The α(2)δ‐1 subunit of voltage-gated calcium channels binds to gabapentin and pregabalin, mediating the analgesic action of these drugs against neuropathic pain. Extracellular matrix proteins from the thrombospondin (TSP) family have been identified as ligands of α(2)δ‐1 in the CNS. This interaction...

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Detalles Bibliográficos
Autores principales: El-Awaad, Ehab, Pryymachuk, Galyna, Fried, Cora, Matthes, Jan, Isensee, Jörg, Hucho, Tim, Neiss, Wolfram F., Paulsson, Mats, Herzig, Stefan, Zaucke, Frank, Pietsch, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838084/
https://www.ncbi.nlm.nih.gov/pubmed/31700036
http://dx.doi.org/10.1038/s41598-019-52655-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838084/
https://www.ncbi.nlm.nih.gov/pubmed/31700036
http://dx.doi.org/10.1038/s41598-019-52655-y

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