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Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit α(2)δ-1 with thrombospondin-4
The α(2)δ‐1 subunit of voltage-gated calcium channels binds to gabapentin and pregabalin, mediating the analgesic action of these drugs against neuropathic pain. Extracellular matrix proteins from the thrombospondin (TSP) family have been identified as ligands of α(2)δ‐1 in the CNS. This interaction...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838084/ https://www.ncbi.nlm.nih.gov/pubmed/31700036 http://dx.doi.org/10.1038/s41598-019-52655-y |