TIP60/KAT5 is required for neuronal viability in hippocampal CA1

Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency in the adult forebrain leads within days to extens...

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Detalles Bibliográficos
Autores principales: Urban, Inga, Kerimoglu, Cemil, Sakib, M. Sadman, Wang, Haifang, Benito, Eva, Thaller, Christina, Zhou, Xunlei, Yan, Jun, Fischer, André, Eichele, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838100/
https://www.ncbi.nlm.nih.gov/pubmed/31700011
http://dx.doi.org/10.1038/s41598-019-50927-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838100/
https://www.ncbi.nlm.nih.gov/pubmed/31700011
http://dx.doi.org/10.1038/s41598-019-50927-1

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