FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia

FTY720 (fingolimod) is a FDA-approved sphingosine analog that is phosphorylated in vivo to modulate sphingosine-1-phosphate receptor (S1PR) signaling for immunosuppression in patients with refractory multiple sclerosis. FTY720 also exhibits promising anticancer efficacy in several preclinical models...

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Detalles Bibliográficos
Autores principales: Young, Megan M., Bui, Van, Chen, Chong, Wang, Hong-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838108/
https://www.ncbi.nlm.nih.gov/pubmed/31699964
http://dx.doi.org/10.1038/s41419-019-2080-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838108/
https://www.ncbi.nlm.nih.gov/pubmed/31699964
http://dx.doi.org/10.1038/s41419-019-2080-5

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