RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

Tumor protein 53 (p53, encoded by the TP53 gene) is a key tumor suppressor regulating cell fates in response to internal and external stresses. As TP53 is mutated or silenced in a majority of tumors, reactivation of p53 by small molecules represents a promising strategy in cancer therapeutics. One s...

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Detalles Bibliográficos
Autores principales: Ristau, Johannes, van Hoef, Vincent, Peuget, Sylvain, Zhu, Jiawei, Guan, Bo-Jhih, Liang, Shuo, Hatzoglou, Maria, Topisirovic, Ivan, Selivanova, Galina, Larsson, Ola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838152/
https://www.ncbi.nlm.nih.gov/pubmed/31699971
http://dx.doi.org/10.1038/s41419-019-2074-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838152/
https://www.ncbi.nlm.nih.gov/pubmed/31699971
http://dx.doi.org/10.1038/s41419-019-2074-3

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